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Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood

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Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial

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Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis

IntroductionSynovitis is the clinical hallmark of rheumatoid arthritis (RA), and the analysis of synovial tissue from affe...

Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits

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Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)

IntroductionDespite the range of disease-modifying anti-rheumatic drugs (DMARDs) that have transformed the therapeutic lan...

Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism

IntroductionAutoinflammatory diseases (AIDs) are genetically determined conditions characterised by recurrent sterile infl...

Correspondence on 'The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease by Wallace et al

IgG4-related disease (IgG4-RD) was initially discovered as a clearly different entity in patients with sclerosing cholangi...

Correspondence on 'NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus by Linge et al

We read with great interest the article by Linge et al 1 on ‘NCF1- 339 polymorphism is associated with altered formation o...

Lessons from negative phase 3 trials in rheumatoid arthritis anno 2023

A recent phase 3 trial (contRAst 3) with otilimab, a drug targeting granulocyte-macrophage colony-stimulating factor (GM-C...

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